The F-16 was participating in routine training at the Nevada Test and Training Range when it crashed at approximately 10:30 a.m. local time, Nellis said in a release.
Officials did not say whether the pilot was able to eject from the single-engine, multirole fighter. The accident is under investigation, the base said.
Nellis has a squadron of F-16C variants assigned to the 64th Aggressor Squadron, which provides combat and adversary air training. The Air Force Thunderbirds, the Air Force’s premiere demonstration team, is also part of the 57th Wing at Nellis.
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The incident is the latest of several aviation mishaps in the last 48 hours.
Also Tuesday, a Marine Harrier jet crashed during takeoff from an airport in Djibouti. The pilot was able to eject and was being treated for injuries, officials told Military.com. It's not clear what prompted the pilot's ejection.
Separately, another CH-53 "sustained minor structural damage" during a landing in Djibouti near of Arta Beach, a military spokesman told CNN on Wednesday.
In September, a pilot was killed in a crash at the Nevada Test and Training Range.
Lt. Col. Eric Schultz, 44, died from injuries sustained in an accident in which an aircraft crashed at the range, located about 100 miles northwest of Nellis Air Force Base.
The aircraft was assigned to Air Force Materiel Command and was flying a training mission at the time of the mishap, according to a release at the time.
The Air Force has never identified the type of aircraft involved in September's crash. Air Force Chief of Staff. Gen David Goldfein would say only that it was not an F-35 Joint Strike Fighter.
"I can definitely say it was not an F-35," Goldfein told Military.com on a trip to the annual conference of the National Guard Association of the United States in Louisville, Ky.
This story will be updated.