Video of a recent test shot of Boeing's ABL test plane shooting down a short-range ballistic missile.
According to a Boeing release...
This experiment marks the first time a laser weapon has engaged and destroyed an in-flight ballistic missile, and the first time that any system has accomplished it in the missile's boost phase of flight. ALTB has the highest-energy laser ever fired from an aircraft, and is the most powerful mobile laser device in the world.And from the Missile Defense Agency:
During the experiment, the aircraft, a modified Boeing 747-400F, took off from Edwards Air Force Base and focused its high-energy laser at the missile target during its boost phase as the aircraft flew over the Western Sea Range off the coast of California.
A short-range threat-representative ballistic missile was launched from an at-sea mobile launch platform. Within seconds, the ALTB used onboard sensors to detect the boosting missile and used a low-energy laser to track the target. The ALTB then fired a second low-energy laser to measure and compensate for atmospheric disturbance. Finally, the ALTB fired its megawatt-class High Energy Laser, heating the boosting ballistic missile to critical structural failure. The entire engagement occurred within two minutes of the target missile launch, while its rocket motors were still thrusting.