Do yourself a huge favor. Grab some popcorn or beer or whatever floats your boat. Give yourself an hour, and watch.
I feel pretty small right now.
If you're interested in the book, The Last Lecture, click here.
If you're having trouble with the YouTube video, which pauses in some spots, you can click here and watch it via Windows Streaming Video or Google Video. I recommend the Windows Video version, I didn't encounter any blips with it. You can fast forward to about eight minutes in when Randy begins his presentation if you choose the Windows Streaming Video. Whatever you do, watch this in its entirety.