Officials say no one on the ground was injured and the Boeing C-17 Globemaster III landed safely at the Jackson airport.
Lt. Col. Christian Patterson of the Mississippi Army National Guard said in a news release the plane lost its tail cone around 7 p.m. Wednesday.
A witness, Wynita Smith, told WLBT-TV the tail cone first hit the street and bounced into a yard.
Patterson said the plane is assigned to Flowood's 172nd Airlift Wing based at Jackson-Evers International Airport.
Patterson says the incident is under investigation.
C-17 is a large military transport aircraft used to transport troops and cargo around the world.